A quantitative research approach was employed to evaluate the effect of a health promotion intervention on college students' knowledge regarding the prevention of coronary artery disease in selected colleges in the Alappuzha district of Kerala, India. The objectives were to assess the knowledge regarding prevention of coronary artery disease, and to determine the effect of health promotion intervention on knowledge regarding prevention of coronary artery disease among college students, and to find out the association between the pre-test score on knowledge regarding prevention of coronary artery disease among college students with their selected demographic variables. Ludwing Von Bertalanffy based the conceptual framework on general system theory. A quantitative research approach was chosen, utilizing a quasi-experimental one-group pre-test-post-test design. The 80 participants were selected using a non-probability convenience sampling technique. The necessary data was collected using a structured questionnaire. The findings were that the mean between post-test knowledge scores of experimental group (p<0.005) indicates that there is a significant increase in the knowledge score of the experimental group on knowledge regarding prevention of coronary artery disease among college students after the structured teaching programme. The association between the knowledge score and various demographic variables shows a 0.05 level of significance. Therefore, there will be significant association between the pre-test level of knowledge scores of college students regarding prevention of coronary artery disease with their selected demographic variables such as gender, personal habits and diet. © 2025 Elsevier B.V., All rights reserved.