Natural Plant species and traditional methods are valuable in the medical field to control various diseases. Recently natural plant-based medicines have received major attention in the medical research field and act as a vital part of healthcare. Also, these natural bioactive compounds are the basic molecules for the new drug synthesis. But the researchers are facing problems such as species identification, isolation of active compounds and their medicinal action in different therapeutic fields in research. This work investigated the completed research and its outcomes of the identification of new biologically active plants and their active parts. Based on the social problem, this review also investigated the Simarouba Glauca plant extraction, isolation of active compounds from the plant and phytochemical analysis of the reported research outcomes. Because, global health challenging illnesses like cancer, diabetes and AIDS are increasing due to the lacking of synthetic medicines. So the new researchers are concentrating on natural plants, algae and sea living organisms for drug development. Hence this work concentrated to identify the usefulness of Simarouba Glauca plant and different work carried on the plant products. These kinds of plant extracts are tested for various biotechnology methods to evaluate its drug suitability. © 2020 Elsevier B.V., All rights reserved.