The primary natural resource we use in our daily lives for a variety of activities is freshwater for drinking and various developmental goals. Furthermore, the pace of human population increase worldwide is rising rapidly and has a great impact on the Earth's natural resources. Natural water quality has diminished owing to various anthropogenic activities. Water is crucial to the life cycle. On the other hand, chemical and agricultural industries pollute heavy metals. Acute and chronic diseases caused by heavy metals, such as slow metabolism and damage to the gills and epithelial layer of fish species, are divided into two categories. Pollutants can also harm liver tissues and result in ulceration as well as diseases such as fin rot, tail rot, and gill disease. The most prevalent heavy metals are As, Cr, Pb, and Hg, which are systemic toxicants that affect human health. These metals are categorized as carcinogens by the US Environmental Protection Agency and the worldwide agency for cancer research because they cause organ damage even at low exposure levels. The focus of the current study is to review various freshwater sources of heavy metal pollution. This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine