This article looks at the zoonotic paramyxovirus known as Hendra virus (HeV) was initially discovered in Hendra, Queensland, which is located in Australia, in 1994. In the Paramyxoviridae family and Mononegavirales order, HeV is the first member of the recently formed Henipavirus genus. It belongs to a distinct clade together with Nipah virus (NiV) and Cedar virus (CedV). Initially discovered during a severe outbreak affecting horses and humans, HeV has been implicated in numerous equine morbidity cases and occasional human transmission in Australia. This review provides a comprehensive analysis of HeV's clinical features, pathophysiology, transmission pathways, and diagnostic methodologies, emphasizing its substantial effect on animal and human health. Current human treatment strategies for HeV infection are primarily supportive, though emerging antiviral therapies show potential. Furthermore, the creation and application of vaccination for horses represent a crucial advancement in controlling the spread of this deadly virus. This review highlights the necessity for continued surveillance, research, and preventive measures to manage HeV outbreaks and safeguard public health. © 2025 Elsevier B.V., All rights reserved.