Background: In the etiopathogenesis of essential hypertension, blood pressure, serum uric acid and lipid peroxidation seemed to be interrelated. However, no study has been performed to assess the role of uric acid in pathophysiology of borderline essential hypertension. Methods: 50 cases of essential hypertension and 25 age and sex matched controls were studied. Serum uric acid, lipid profile and routine biochemical parameters were measured by semiautoanalyzer, creatinine clearance was calculated by Cockcroft-Gault algorithm and serum MDA was measured by spectrophotometry. Results: Serum creatinine, uric acid, lipid components were significantly high and creatinine clearance was significantly low in the hypertensives. Serum uric acid was positively correlated with systolic blood pressure (r = 0.314; p<0.05), serum urea (r = 0.31; p<0.05), serum creatinine (r = 0.534; p<0.001), MDA (r = 0.289; p<0.05) and triglyceride (r = 0.274; p<0.05) were negatively correlated with creatinine clearance. Serum MDA was positively correlated to serum urea (r = 0.007; p<0.05) and serum creatinine (r = 0.453; p<0.001) and negatively correlated with creatinine clearance (r = 0.273; p<0.05). About one-third of the patients (30%) had hyperuricemia. Conclusion: Serum uric acid and MDA levels used as marker is for early diagnosis and intervention of essential hypertension. © 2011 Elsevier B.V., All rights reserved.