Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Verapamil Hydrochloride is widely used in the management of Hypertension, Angina pectoris and Myocardial infraction The present investigation concerns the development of Buccoadhesive tablets of Verapamil Hydrochloride which were designed to prolong the buccal residence time after oral administration. Buccal tablets of Verapamil Hydrochloride were formulated using four mucoadhesive polymers namely, Carbopol 934 P, HPMC K<inf>4</inf>M, Hydroxy ethyl cellulose and Sodium corboxymethylcellulose carried out studies for weight variation, thickness, hardness, content uniformity, swelling index, Bioadhesive strength and in vitro drug release. Formulation of F6 were formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose provided controlled release of Verapamil Hydrochloride over period of 8 hrs. The cumulative % of drug release of formulation F6 was 97.01. In-vitro releases of F6 was found to be diffusion controlled and followed zero order kinetics. The stability studies of formulation F6 showed that there was no significant change in adhesive strength, in-vitro release when stored at room temperature and 40°C, for a period of 30 days. Formulation of F6 which was formulated by using polymers Carbopol 934 P and Hydroxy ethyl cellulose was established to be the optimized formulation with optimum bioadhesive strength, swelling index & desired in-vitro drug release. © 2010 Elsevier B.V., All rights reserved.