Anandan, Ramasamy (35309372900) and Jayakar, Balasundaram (6603630993) and Karar, Biusan (35310820300) and Babuji, Seevalen Shahul Hamid (9746465400) and Manavalan, Rajappan (8588686300) and Kumar, Raju Senthil (22934867400) (2009) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL 4 induced hepatic injury in rats.
Full text not available from this repository.Abstract
Hepatoprotective activity of ethanolic extract of flowers of Vitex trifolia (Verbenaceae) was studied against CCl<inf>4</inf> induced hepatic injury in albino rats. The plant extract (EVT) at the dose of 200 mg/kg, p.o. showed a remarkable hepatoprotective activity. CCl<inf>4</inf> induced a significant rise in serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Treatment of rats with EVT significantly (P<0.001) altered serum biomarker enzyme levels to near normal against CCl<inf>4</inf> treated rats. The activity of the extract was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Histopathological observations also revealed that treatment with EVT protected the animals from CCl<inf>4</inf> induced liver damage. The results indicate that the flowers of V. trifolia possess hepatoprotective activity on CCl<inf>4</inf> induced hepatic injury in rats. © 2010 Elsevier B.V., All rights reserved.; MEDLINE® is the source for the MeSH terms of this document.
| Item Type: | Article |
|---|---|
| Subjects: | |
| Divisions: | Pharmacy > Vinayaka Mission's College of Pharmacy, Salem > Pharmacy |
| Depositing User: | Unnamed user with email techsupport@mosys.org |
| Last Modified: | 11 Dec 2025 06:17 |
| URI: | https://vmuir.mosys.org/id/eprint/5191 |
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