Chandira, Margret R. (36112855500) and Venkateswarlu, Bendi Sri (57196663459) and Shankarrao, Jadhav Anup (36176077900) and Bhowmik, Debjit (57190894137) and Jayakar, Balasundaram (6603630993) and Narayana, T. V. (35757941500) (2010) Formulation and evaluation of extended release tablets containing metformin HCl.
Full text not available from this repository.Abstract
Extended release dosage forms cover a wide range of prolonged action preparations that provide continuous release of their active ingredients for a specific period of time.Metformin Hcl is antihyperglycemic agent used in the treatment of type 2 Non Insulin Dependent Diabetes Mellitus. The extended release formulation of Metformin Hcl (MER), prolongs drug absorption in the upper gastrointestinal tract and permits once daily dosing in patient with Type 2 Diabetes Mellitus.This newer formulation may enhance patient compliance with oral therapy compared to conventional immediate release (MIR) Metformin Hcl in Type 2 Diabetes Mellitus Extended release formulation of Metformin Hcl presents significant challenges due to its poor inherent compressibility, high dose and high water solubility. Extended release matrix tablet of Metformin Hcl were formulated different combinations of polymers in Hydroxyl propyl methyl cellulose (HPMC K 100M CR) and Carbopol 71 G by wet granulation method. The formulated granules blends were evaluated for compatibility, Angle of repose, True density, Bulk density, Compressibility index. The formulated tablets were subjected to Thickness, Weight variation test, Hardness test, Friability test and Drug content. Invitro dissolution studies carried out in 6.8 phosphate buffer using the apparatus Type 2 paddle type as described in the USP dissolution monograph. Formulations F1, F2 and F5 showed sudden drug release which might be due to low level of the polymer in the tablets. Formulations F7, F9 and F10 containing HPMC K 100 M CR and Carbopol 71G in different concentration shows the extended drug release for up to 10 hrs, among these formulation, F10 is considered as optimized formulation because it shows similar drug release pattern with that of innovator. There was no significant change in physical and chemical properties of the tablets of formulation F10 after 3 Months, parameters like % drug release and assay values at various conditions as per ICH guidelines. © 2013 Elsevier B.V., All rights reserved.
| Item Type: | Article |
|---|---|
| Subjects: | Medicine > Pharmacology |
| Divisions: | Pharmacy > Vinayaka Mission's College of Pharmacy, Salem > Pharmacy |
| Depositing User: | Unnamed user with email techsupport@mosys.org |
| Last Modified: | 11 Dec 2025 06:17 |
| URI: | https://vmuir.mosys.org/id/eprint/5174 |
