The objective of the present study was to develope sustained release matrix tablets of baclofen, for treatment of spastically resulting from multiple sclerosis, flexor spasm and muscular rigidity. The matrix tablets were prepared by wet granulation method using hydroxypropyl methylcellulose K4M, K100M and Xanthan gum in various concentrations. The granules showed satisfactory flow properties and compressibility. All the nine formulations showed acceptable pharmacopoeial standards. The result of formulation B7 (25% hydroxypropyl methylcellulose K4M and K100M) extented the release of baclofen up to 12hrs.Model fitting analysis for formulation B7 fitted in the zero order model and korsemeyer- peppas model. The 'n' values obtained from the peppas-korsemeyer equation suggested that, drug release was non-Fickian difussion mechanism. Successful formulation was found stable after evaluation for physicochemical parameters when kept for 30 days at room temperature 40°C and 2-8°C. It concluded that sustained release matrix tablets of baclofen containing 25% of HPMC K4M and HPMC K100M provide a better option for extended release of drug. © 2011 Elsevier B.V., All rights reserved.