The effect of Chandra nadisuddhi pranayama was studied on a yoga practitioners and a naïve subject. Chandra nadisuddhi pranayama is simply a left nostril breathing exercise. The heart beat rate was taken immediately before and immediately after each session, which consisted of twelve cycles of Chandra nadisuddhi pranayama. The mean heart beat rate of the yoga practitioners dropped from 73.94 ± 2.71 to 65.89 ± 2.02 and that in the naïve subject dropped from 79.83 ± 3.26 to 76.14 ±2.31 after Chandra nadisuddhi Pranayama. The drop was significant at p<0.001 in both the cases. But the drop was high in case of the yoga practitioners. So, it has been concluded that the effect of pranayama is the same in all, but to a higher degree in experienced yoga practitioners than in a naïve person. © 2011 Elsevier B.V., All rights reserved.