Atenolol is β1-selective adrenergic blocking agent and widely used in the treatment of hypertension and angina pectoris.Therefor the present investigation was to design a formulation of Mouth dissolving tablet of Atenolol. Mouth dissolving tablets of Atenolol were formulated by Effervescent method, Superdisintegrant addition method, Sublimation method, hot melt method and solid dispersion method by direct compression technique. All the five formulations were evaluated for disintegration time, hardness and friability, among this Superdisintegrant addition method exhibits the lowest disintegration time, hence it is ranked as the best among the five methods. Further nine batches were prepared by using sodium starch glycolate and Ac-di-sol in different concentration. All the formulations were evaluated for weight variation, hardness, friability, drug content, invitro disintegration time, wetting time, in-vitro dissolution study. Among all the formulation B7 (containg containing Sodium Starch Glycolate (4%) and Ac-di-sol (3%) was considered to be the best formulation, which release up to 99.90% of the drug in 10 min. © 2011 Elsevier B.V., All rights reserved.