Depressive disorder produces substantial and lasting decrements in many domains of functioning, especially, perceived stress, self efficacy and well being. 60 patients (28 males and 32 females) who came to the hospital for treatment were selected for the administration of Mindfulness based self control therapy (MBSCT). Perceived stress, self-efficacy and well being scales were used in the before, after, and follow-up assessments repeatedly. The intervention program was used for 14-17 sessions, each consisting of 45 minutes for the improvement in depression, perceived stress, self-efficacy and well being state. Besides, coping with their specific problems was done through phone. The results showed that they had significant changes in all areas of functioning after the intervention and improvement in the mood disorder, perceived stress, self efficacy and well being. The male and female patients maintained the improvement well at the follow up except the general self efficacy. The therapy might be useful to make them have self management effectively and to prevent relapse of depressive disorder of the patients. © Journal of the Indian Academy of Applied Psychology. © 2012 Elsevier B.V., All rights reserved.