In the present study hydrodynamically balanced system of antiparkinson drugs was developed as single unit floati4/20/2011ng capsule. Various grades of low density polymers were used for formulation of this system. The formulation was prepared on the basis of in vitro buoyancy and in vitro drug release profile in 0.1N HCl. Buoyancy study of formulated capsule was achieved over a period of 12 hrs. The effect of additional low density grade polymers on drug release pattern and swelling index were also studied. The effect of change in polymer concentration and effect of different grades of polymer with the use of intra granularly and extra granularly were also studied. Initial 3 batches with the use of direct mix was not showing acceptable flow property with different diluents. The granulometry property was acceptable with the wet granulation method. Dissolution profile and swelling index were matched with the reference by different grades of polymers. But formulation failed in stability so strategy was changed to pelletization technique. Drug was granulated with binder and drug granules were coated with the HPMC 6cps to avoid direct contact of drug with atmosphere. Other excipients like BHA, BHT and citric acid were added to reduce impurities. Capsule prepared with HPMC K15 M, HPMC K100 M and citric acid gave best drug release with controlled impurities. © 2009 by Sudarshan Publication Sudarshan Institute of Technical Education Pvt. Ltd. © 2011 Elsevier B.V., All rights reserved.