The aim of the present work was to design and development of hydrodynamically balanced tablet of cefuroxime axetil to enhance the bioavailability and therapeutic efficacy of the drug. cefuroxime axetil is classified as a second-generation cephalosporin antibiotic and beta lactum antibiotics based on spectrum activity. Tablets are prepared by the direct compression technique by using HPMC K4M and mannitol as polymers along with sodium bi carbonate as gas generating agent. Formulation were evaluated for in vitro byoyancy and drug release study using up dissolation apparatus using 0.1N Hcl as a medium. The result indicate that floating tablets of dissolation cefuroxime axetil containg 45mg HPMC K4M provides a better option for control release action and improved bioavailability. © 2009 by Sudarshan Publication. © 2011 Elsevier B.V., All rights reserved.