Clindamycin is an excellent drug which can be used for the treatment of skin and soft tissue infections which are caused by Gram positive cocci and it also serves as an alternative for penicillin in penicillin allergic patients. Clindamycin resistance may be inducible or constitutive. Inducible resistance cannot be detected by the routine antimicrobial susceptibility tests or by the disc diffusion method. This study was undertaken to study the prevalence of inducible resistance in Gram positive cocci by the D test as per the CLSI guidelines. 73(42%) out of the 168 consecutive isolates of MRSA, MSSA, CONS, S.pneumoniae and S. pyogenes were erythromycin resistant. 27(16%) isolates showed inducible clindamycin resistance and a higher percentage was noted in MRSA (28%) as compared to MSSA (12%) and CONS (14%). This study indicates the importance of the D test in detecting inducible clindamycin resistance in Gram positive cocci and to use it as an aid in the optimal treatment of the patients. © 2011 Elsevier B.V., All rights reserved.