Aim: Menopause is the phase of declined ovarian activity & fall in estrogen level. Since there is an increased risk of cardiovascular diseases for women after menopause, the present study was carried out to evaluate the lipid profile status and associated changes in the left ventricular function in Postmenopausal women. Design-: Descriptive Study. Setting: 100 Postmenopausal were selected for study group, they are sub grouped into Postmenopausal <5years (N=50), Postmenopausal>5years (N=50), according to the number of years attained after menopause. Normal reproductive age group women (N50) were selected as control. Materials & Methods: For both the study groups & control, we have measured Body Mass Index,Waist-Hip Circumference Ratio, Blood lipid profile including Total cholesterol, Triglycerides, Low density lipoprotein (LDL) & High density Lipoprotein (HDL).The Lipid parameters have been estimated by Enzymatic calorimetric method. The contractility indices of Left ventricular function like Fractional Shortening, Ejection Fraction & Left ventricular mass index were assessed by M-Mode Echocardiography. Statistical Analysis: Statistical analysis was done by one way ANOVA test. Results: BMI, W/H Ratio, were found elevated in both the sub groups menopausal women <5 years and >5 years. Among the lipid profile, Total cholesterol is elevated significantly (P < 0.05), in both the sub groups. In Postmenopausal women -> 5 years, LDL cholesterol value was significantly elevated than Postmenopausal <5 years & control. Echocardiographic findings revealed that there is a significant reduction of Fractional shortening in & Postmenopausal ->5years. Conclusion: Postmenopausal women of longer duration (>5years), was the LDL Cholesterol significantly raised, the LV Functions shows significant negative correlation. The derangement in lipid profile status is observed markedly in postmenopausal women of longer duration and the LV function significantly and negatively correlates to the lipid profile status in those postmenopausal women> 5 years. © 2011 Elsevier B.V., All rights reserved.