The present study is to know the frequency, causative bacteria and their sensitivity pattern in S.S. Hospital, Davangere. A prospective study was conducted between April to September 2010 in the department of microbiology, SSIMS and RC, Davangere. Endotracheal aspirate samples were collected from a total of 369 patients under mechanical ventilation for >48hrs who were suspected of having ventilator associated pneumonia(VAP) and were processed and identified by standard laboratory techniques.quantitative culture threshold of >10 3cfu/ml was considered to diagnose ventilator associated pneumonia in our study. Out of the 369 patients studied, quantitative culture was positive in 166(44.99%), 143 cases(38.75%) showed no growth and in 60 cases(16.26%) growth was <10 3both of which were included under No Ventilator associated pneumonia(NO-VAP) group. Out of 166 culture isolates, Pseudomonas species 56(33.73%) was the most common, followed by Klebsiella, pneumoniae 28 (16.87%), Acinetobacter species20 (12.05%), Escherichia. Coli 16(9.64%), Meticillin resistant Staphylococcus aureus 9(5.42%) and Citrobacter.freundii 7(4.21%). Organisms showed sensitivity to imepenam,ceftazidime,cefoperazone-sulbactam and amikacin.Most common age group affected was 21-30 years (28.46%) and in males with male to female ratio being 1.95:1.Most common indication for admission was poisoning(42%) followed by preterm with low birth weight (18%). © 2012 Elsevier B.V., All rights reserved.