Background and objectives: Earlier studies have shown that the reaction time for auditory and visual stimuli are delayed in diabetic individuals. Materials and Methods: 60 (30 male and 30 female) uncomplicated type 2 diabetic individuals of age group 40-60 years were selected as subjects. 60 (30 male 30 female) age, physical activity matched individuals were selected as controls. Alcohol consumption, cardiovascular and respiratory illness were excluded. The auditory reaction time (ART), Visual Reaction Time (VRT), Discriminative Reaction Time (DRT) in healthy individuals and type 2 diabetic patients were determined and results were compared. Results: Statistically significant increase in Reaction Time in type 2 male diabetic patients was observed for ART right hand (p=0.01) left hand (p=0.003) VRT red for left hand (p=0.003) DRT red/green right hand (p=0.00019) left hand (p=0.00044). There was statistically significant increase in reaction time in type 2 female diabetic patients. For ART right hand (p=0.0012) left hand (p=0.0043) VRT red right hand (p=0.0004) left hand (p=0.001). VRT green right hand (p=0.00007) left hand (p=0.004). DRT red/green for right hand (p=0.00019) left hand (p=0.00044) DRT green/red for left hand (p=0.0015). Conclusion: Delayed reaction time in diabetics without clinical neuropathy can be taken as a sensitive indicator of early nerve damage. © 2013 Elsevier B.V., All rights reserved.