Major depressive disorder takes a big toll in human life. It is imperative to treat depressed patients with medications and psychological therapy. The study assessed the impact of two groups, one with medications, and the other group with medications and psychosocial intervention. The sample was divided into pharmacotherapy group, and pharmaco and psychosocial intervention group of depressed male patients. In the psychosocial intervention, the patients attended the programs three days in a week for three months and later on once in a month with their informants. Level of functioning was determined at before, after and follow-up1 and follow-up 2 using the following scales a) Type D Personality Scale, b) Quality of life Scale and c) The report of family member which was also used to assess the patient's ability to stay out of the problem at home, dysfunction in work, and the ability to lead a quality life. The scores on the levelof-functioning were significant between before and after, after and follow-up1and follow-up2. Statistical tests indicated a substantial and significant increased in level of functioning from before to follow up2 for all groups. Both the depressed patients and their relatives could benefit from family psychosocial intervention and for the compliance of pharmacotherapy. Nevertheless, the method of intervention which took care of treatment and also efforts to change their coping was much more effective in changing negative affectivity and social inhibition. © Journal of the Indian Academy of Applied Psychology. © 2012 Elsevier B.V., All rights reserved.