A new, simple and precise HPLC method was developed for the determination of Lafutadine and Domperidone in capsule dosage form. Reversed phase chromatography was performed at Phenomenex, C18, 5μ particle size, 250 × 4.6 mm column as stationary phase and the mobile phase consist of 0.02 M Potassium dihydrogen phosphate: Acetonitrile: Methanol in a ratio of 50:35:15 v/v/v at the flow rate of 1 ml/min. All the analytes were quantified at 285 nm. Statistical validation of the method included determination of linearity, accuracy and precision. The method is rapid and reproducible and could be used for direct determination of Lafutadine and Domperidone in different dosage forms. © IDOSI Publications, 2012. © 2012 Elsevier B.V., All rights reserved.