AIM:To monitor the adverse effects of oral and topical corticosteroid preparation. Methods: A descriptive study was conducted in outpatients from Rheumatology and Dermatology OPD who were taking corticosteroids for rheumatoid arthritis and chronic eczema for more than 6 months, study was conducted over 6 months period. The WHO definition of an ADR was adopted. Adverse effects were monitored during the study period. The Naranjo algorithm scale was used for causality assessment. Results: Statistical analysis was done by using Microsoft excel. Most common adverse effects observed in oral corticosteroid population were hypertension 46.7%, hyperglycemia 24%, cushingoid feature16%, with causality assessment score 7, 13.3% of peptic ulcer disease with causality assessment score of 6. In topical corticosteroid population adverse effects observed were 60% hyperglycemia, 40% cushingoid feature. Hypertension, peptic ulcer disease were not reported in topical corticosteroid population. This indicates oral and topical corticosteroids were the probable cause of these adverse events. Conclusion: The most common adverse effects observed in oral corticosteroid preparations were hypertension followed by hyperglycemia, cushingoid feature & peptic ulcer disease. For topical corticosteroid preparation the most common adverse effects were hyperglycemia followed by cushingoid feature. In Indian Population the incidence of hypertension and hyperglycemia were more common and the cushingoid feature appears to be less when compared to the studies conducted in Western population. © IDOSI Publications, 2012. © 2012 Elsevier B.V., All rights reserved.