Objectives: Acalypha indica Linn. L. (family: Euphorbiaceae) is a weed widely distributed throughout the plains of India. It has been reported to be useful in treating pneumonia, asthma, rheumatism and several other ailments. As there is no indication of publications regarding the Anti hyperlipidemic activity of the plant,the present study was designed to investigate the Anti hyperlipidemic activity of ethanolic, aqueous extracts of Acalypha indica Linn. Method: Hyperlipidemia was induced by Atherogenic diet in Wistar albino rats. Drugs were administered in two different dose levels (200mg/Kgbwt, 400mg/ Kgbwt). Results: Though two extracts of Acalypha indica Linn, dose dependently reduced, the elevated levels of TC, TG and LDL-C condition has shown considerable decline. Ethanolic extract (400mg/kg) of Acalypha indica Linn leaves was more significant as compared to aqueous extract. A preliminary phytochemical analysis revealed the presence of different phytoconstituents such as lignands, flavonoids, glycosides, sterols, sugars, amino acids and triterpenoids etc which may important for these activity Conclusion: The present result suggests Acalypha indica Linn. improved the serum lipid profile in rats by decreasing serum TC, TG, LDL-C and increasing serum HDL-C, thus improving the atherogenic index. This finding provides some biochemical basis for against hyperlipidemia. Further, studies are required to again more insight in to the possible mechanism of action. © 2025 Elsevier B.V., All rights reserved.