Introduction: Passive smoking, second hand smoking or environmental tobacco smoking is considered to be equally or more hazardous than active smoking. Due to direct and indirect stimulation of sympathetic system it leads to dyslipidaemia or affects heart directly. The different chemicals present in side-stream of smoke are either oxidants themselves or may lead to generation of free radicals that ultimately gives rise to cardiovascular disorders. Aim: A case-control study was taken up with the objective to learn about oxidative stress and the extent of cardiovascular risk in the passive smokers. Methodology: 50 apparently healthy passive smokers and 50 non-smokers in the age group 16 to 25 years were chosen and their routine investigations, lipid profile, serum uric acid and oxidative stress marker MDA (Malondialdehyde) were assayed to see the correlation between passive smoking, oxidative stress and cardiovascular risk factors. Result: In passive smokers total cholesterol and MDA were high & statistically significantly (p< 0.001). MDA was found statistically significantly correlated to TC (r=0.33; p< 0.01), LDL-C (r=0.35; p< 0.01), Non - HDL-C (r= 0.3; p<0.01). Also MDA was found to be positively correlated to SBP, DBP and respiratory rate that were statistically significant. Passive smoking was found to be strongly associated with hypercholesterolaemia (OR= 17.2; p< 0.001, CI= 95%) and oxidative stress (OR= 38.5; p< 0.001, CI= 95%). Duration of exposure to smoking is significantly associated with oxidative stress marker MDA (OR= 17.93, p<0.0001; CI= 95%). Conclusion: Passive smokers have a potential risk to develop oxidative stress and dyslipidaemia which may lead to cardiovascular disorders in the long run. © 2013 Elsevier B.V., All rights reserved.