The aim of the study was to investigate phytochemicals and GCMS analysis of ethanolic extract of Cycas circinalis and Ionidium suffruticosum. The bioactive constituents were traced out in C.circinalis and I.suffruticosum by phytochemical screening (qualitative methods) and the GCMS method. C.circinalis showed the presence of terpenoids, flavonoids, cardiac glycosides, Phytosterols, amino acids, and alkaloids. In GCMS analysis C.circinalis showed 16 bioactive components with high concentration of α-D-Glucopyranoside, α -D-glucopyranosyl (77.73%), Decanoic acid, ethyl ester (11.92%) whereas I.suffruticosum showed the presence of tanins, flavonoids, terpenoids, saponin, cardiac glycosides, amino acids and alkaloids. In GCMS analysis I.suffruticosum showed 18 bioactive components with high concentration of 3-Trifluoroacetoxydodecane (16.76%), 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (15.32%), Decanoic acid, ethyl ester (14.98%), E-2-Tetradecen-1-ol (10.46%), Spiro[2.2]pentane-1-carboxylic acid, 2-cyclopropyl-2-methyl (5.01%), 2H-Pyran, 2-(7-heptadecynyloxy)tetrahydro (8.31%), Squalene (6.24%). The phytochemical constituent’s common in both C.circinalis and I.suffruticosum was Decanoic acid, ethyl ester and 3-Trifluoroacetoxydodecane. The presence of some of these bioactive constituents in the plant extract may provide the scientific evidences for many medicinal effects of these plants. © 2014 Elsevier B.V., All rights reserved.