The hepatoprotective effect of ethanolic leaf extract of Trigonella foenum graecum and curcuma Zeoderia against paracetamol induced hepatic damage in albino rats was investigated. Ethanolic extracts from the leaves of Trigonella foenum graecum and curcuma Zeoderia at a dose level of 100mg/ml was administered orally daily once for 5 days as pretreatment and no side effects or injury to any organ was observed. Paracetamol at a single dose level of 500mg/kg body weight was given intraperitonially to induce hepatotoxicity. The substantially increased serum marker enzymes like Aspartate transaminase, Alanine Transaminase, Alkaline phophatase, Gamma glutamyl transferase, Lactate dehydrogenase, Creatine phosphokinase due to paracetamol treatment was restored towards normalization in rats treated with leaf extracts of Trigonella foenum graecum and curcuma zeoderia. Similarly the elevated levels of blood urea, serum creatinine, serum cholesterol, serum TGL due to paractamol intoxication was returned to normal when rats treated with the leaf extracts. Paracetamol induced hepatotoxicity causes the failure of the synthetic function of the liver which leads to Hypoproteinemia and hypolbuminemia. The protein levels are returned to normal when treated with the ethanolic leaf extracts. Due to paracetamol intoxication the reduced of non enzymic autioxidants such as Ascorbic (Vit.C), α – Tocopherol (Vit.E), GSH was restored to the normal level in rats treated with the leaf extracts. Paracetamol administration in rats also increased the lipid peroxidation process and results in imbalance in redox status due to oxidative stress which is evident from, the elevated values of TBARS. Enzymic antioxidant such as SOD, catalase, GPx levels reduced in rats treated with paracetamol was restored towards normal when animals treated along with the leaf extracts. The results of this study clearly showed that the ethanolic leaf extracts of Trigonella foenum graecum and curcuma zeoderia has got a potent hepato-protective effect against paracetamol induced liver injury in albino rats. © 2015 Elsevier B.V., All rights reserved.