In the present research work controlled release Microspheres Containing Acid Resistant Polymers of balsalazide were formulated. Balsalazide is delivered intact to the colon where it is cleaved by bacterial azoreduction with pH-dependent solubility. To achieve pH independent drug release of Balsalazide, pH modifying agents (buffering agents) were used. After a long process comprising preformulation study followed by subsequent formulation and evaluation pharmaceutically elegant and technologically competent controlled release system of chitosan and alginate polyelectrolyte complex microspheres were developed and further forwarded to propose a convenient oral solid dosage form to suffice the needful purpose of achieving site specific and sustainable delivery of balsalazide for treatment of colon related disorders. Thorough evaluation process related to performance of microsphere to show optimum swelling and mucoadhesive property with sufficient control over drug release pattern led to selection of suitable candidate and capacity of prepared enteric coated tablet to provide safe and optimum carriage of microspheres to colon where sustained release of balsalazide was expected. © 2017 Elsevier B.V., All rights reserved.