The objective of present study was to Design Buoyant type of Gastro retentive dosage forms of Ranolazine. The biggest problem in oral drug delivery is low and erratic drug bioavailability. The ability of various polymers to retain the drug when used in different concentrations was investigated. Hydroxypropyl methylcellulose (HPMC K4M), HPMC K100 M, Xanthan Gum and Guar Gum were evaluated for their gel forming abilities. In this work sodium bicarbonate is used as gas generating agent, Citric acid as to provide acidic medium at elevated pH levels of fed stomach and Stearic acid as a release rate retardant material. In vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow both the Higuchi and the Korsmeyer and Peppas equation. The drug release mechanism was found fickian type in most of the formulations. © 2017 Elsevier B.V., All rights reserved.