Sekar, Balakrishnan (55328820600) and Saranyan, R. (56800878400) and Nirmal, Ramadas Madhavan (57209359734) and Indrapriyadharshini, Kumaresan (57199751071) and Murugesan, Ambika (57205392547) and Yoithapprabhunath, Thuckanaickenpalayam Ragunathan (56052979900) (2019) Cancer-associated fibroblast (CAF) expression in metastatic and non-metastatic oral squamous cell carcinoma (OSCC)-a determinant in cancer progression.
Full text not available from this repository.Abstract
Background: Tumour stroma plays a vital role in carcinogenesis. Myofibroblastic expression in stromal fibroblast (cancer-associated fibroblast, CAF) is associated with poor clinical outcome was observed in previous studies. Aim: To evaluate and compare the expression of alpha smooth muscle actin (α-SMA) in non-metastatic and metastatic oral squamous cell carcinoma (OSCC). Materials and Methods: A retrospective study was conducted in 100 formalin fixed, paraffin embedded tissue blocks which includes 50 metastatic and 50 non-metastatic OSCC. α-SMA expression was observed on the basis of proportion and intensity in the tumour stroma. Results: α-SMA shows significantly increasing expression from non-metastatic to metastatic OSCC. Statistically significant expression of α-SMA (p<0.001) was observed in metastatic OSCC. Conclusion: Expression of α-SMA in tumour stroma suggests a positive role of myofibroblast in tumour progression and a potential target for the therapeutic purpose. © 2020 Elsevier B.V., All rights reserved.
| Item Type: | Article |
|---|---|
| Subjects: | Biochemistry, Genetics and Molecular Biology > Cancer Research |
| Divisions: | Medicine > Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem > Microbiology |
| Depositing User: | Unnamed user with email techsupport@mosys.org |
| Last Modified: | 11 Dec 2025 05:59 |
| URI: | https://vmuir.mosys.org/id/eprint/4629 |
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