Medical students have found distance learning to be a difficult challenge as a result of the coronavirus disease 2019 (COVID-19) pandemic. This study investigated the correlation between academic performance, sleep quality, and burnout among Medical students who participated in distance learning during the COVID-19 pandemic. The study included 154 Medical students at Government Erode Medical College in Tamilnadu, data were collected in June 2021. The survey was conducted using a Google Forms containing informed consent along with Demographic Details, self-rated sleep quality, academic performance, and The Maslach Burnout Inventory –Student Survey burnout questionnaire. Correlation between academic performances, sleep quality, Emotional Exhaustion, Cynicism, and Academic Efficacy was analyzed using Karl Pearson correlation method. 18% of students experienced severe burnout during distance learning. 60% of students don’t like online classes. More than 60 % internal mark scored students (P=0.02) are having significantly high Academic Efficacy Scores. Cronbach’s Alpha is 0.7498. Distance learning was reported a significant negative impact on their academic performance. To develop a favourable learning environment for medical students, medical instructors should consider creative learning methodologies. © 2021 Elsevier B.V., All rights reserved.