Hypothyroidism has a high degree of prevalence in India and is also associated with many comorbidities. The current study was planned to find out the incidence, knowledge, awareness, manifestations, and comorbidities in hypothyroid patients. A community-based cross-sectional observational study was conducted in Vinayaka mission’s Kirupananda Variyar medical college and hospital. This includes a study population of 100 consecutive hypothyroid patients. Detailed information regarding, age, family history, habits, knowledge of hypothyroidism and its manifestations along with comorbid conditions were collected and statistically analysed to determine differences in the gender, symptoms, and comorbidities between the two groups of the study population. It was observed from the results that the incidence of hypothyroidism was high in females (71%) than males 29%. Most of the hypothyroid patients were found to be in the age of 31-40 years (36%). Hair loss was found to be the most common symptom present in both genders. Obesity was the major comorbidity in women (56.33%) and sleep apnoea (75.86%) in male patients (75.86%) respectively. Family history of hypothyroidism was high in female patients (67.50%) than in male 3(2.50%) patients. Knowledge and awareness about hypothyroidism were more in female than male patients. High prevalence was observed in female patients and had more awareness about hypothyroidism than male patients It was highly recommended that early screening tests for diabetes, obesity hypertension, asthma, and other hematologic tests will helpful for the early diagnosis and management of comorbidities associated with hypothyroidism. © 2022 Elsevier B.V., All rights reserved.