Pigmentary mosaicism is a term that describes various patterns of segmental pigmentation disorders based on genetic heterogenicity of skin cells. Pigmentary mosaicism is a collective term, which comprises phenotypes represented by mosaic hypo- and/ or hyperpigmentation in the form of whorls, patchy, streaks or more bizarre skin configurations. Melanocyte precursors are neural crest derived and migrate through the Dorso-lateral pathway during embryogenesis. This group of disorders may be associated with or without systemic abnormalities. In a considerable number of cases, pigmentary mosaicism is observed alongside extracutaneous oddities generally affecting the musculoskeletal system and central nervous system. Pigmentary mosaicism includes a variety of inherited, patterned pigmentary dermatoses which have been described using various terms such as hypo melanosis of Ito, linear and whorled nevoid hypermelanosis, phylloid hypo- and hypermelanoses and pigmentary mosaicism of both hypopigmented and hyperpigmented type. Here, we present a series of 5 cases of pigmentary mosaicism in a single report. © 2025 Elsevier B.V., All rights reserved.