Introduction Lichen planus [LP] is a papulosquamous disease which is prevalent all over the world. Although its not a fatal disease, it is having a considerable influence on the health related quality of life (QOL) but it remains under evaluated. Objective The present study was conducted to study the clinico-epidemiological features and the effect of lichen planus on the QOL of patients in a tertiary care hospital. Methods This was a cross sectional study, conducted between April 2018-April 2019. A total of 84 patients with lichen planus of were included in the study. Quality of life was assessed by using dermatological life quality index (DLQI) questionnaire. Results The 84 patients with LP formed 0.56% of the total number of new dermatology out patients. The male: female ratio was 1:0.95. The patient age ranged from 8 to 72 years, most being in the age range from 41-70 years (53.6%). The majority of the patients (50%) showed classical lesions followed by hypertrophic type(19%) next in frequency. Most patients (85.7%) had pruritus. Regarding Dermatological Life Quality Index (DLQI), most of the patients that is, 47 cases (56.0%) had moderate effect on quality of life, 28 (33.3%) had very large effect on quality of life and 9(10.7%) had small effect on quality of life. Conclusion This study depicts that LP is having impact on the quality of life and its mainly attributed to the symptom (pruritus) and also the cosmetic disfigurement caused by these lesions on extremities.