The newer innovations play an important role in the earlier diagnosis of dental caries based on near-infrared transillumination imaging such as Diagnocam and Soprocare intraoral digital cameras, which aid in the diagnosis of dental caries and also differentiate old and newer dental plaques, respectively. Nanoparticles used as carriers for effective and targeted drug therapies in the treatment of rheumatoid arthritis of the temporomandibular joint (TMJ) and candidiasis among chronic denture wearers provided better-increased bioavailability than oral formulations. Artificial intelligence (AI) uses machines to simulate intelligent human behavior. Augmented reality has been presented as a cognitive extension of AI in health care, emphasizing the auxiliary and supplemental roles of dental and medical practitioners. The article enlightens readers with newer diagnostic methods in dentistry and medicine and innovations such as Surface Topography-Assisted Robotic Superstructures (STARS), Prostate-Specific Membrane Antigen Ligand Positron Emission Tomography/Computed Tomography (PSMA-PETCT), toothbrushes with augmented reality, new hydro-gel-based electrodes for Brain-Computer Interface (BCI) applications, and robotics in dentistry.