Pyogenic Granulomas (PG) are common benign vascular tumors of skin and mucous membrane which commonly presents in children and young adults. Clinically PG presents as friable, erythematous papule or nodule located on the head and upper extremities with a tendency to rapidly grow and bleed with minor trauma. Usually, PGs are treated with surgical excision. Here we report a case where topical application of 0.5% timolol drops led to complete resolution of PG of lower lip in a young adult with no recurrence at 3 months. © 2023 Elsevier B.V., All rights reserved.