The reproducibility crisis across multiple disciplines has underscored the urgent need for systematic transparency mechanisms in research practices. Functional research registries have emerged as critical infrastructure for embedding accountability, traceability, and openness into the research lifecycle. This conceptual paper examines the key components that define an effective registry system, including mandatory pre-registration, protocol versioning, metadata standardization, and the assignment of persistent identifiers. It highlights the evolving role of libraries and information science professionals as stewards of registry services, facilitating compliance, metadata curation, and data stewardship. While the benefits of registries are substantial, significant barriers persist, including concerns over intellectual property, bureaucratic resistance, funding limitations, and infrastructural challenges, particularly in low- and middle-income contexts. Future directions explore how emerging technologies such as blockchain and artificial intelligence can fortify the functionality and security of registries, while global policy harmonization could foster an interoperable ecosystem that transcends disciplinary and geographic boundaries. Ultimately, the widespread adoption and institutionalization of functional research registries are essential for cultivating a more transparent, reproducible, and inclusive global research culture, ensuring the integrity and sustainability of scientific knowledge in the digital age. © 2025 Elsevier B.V., All rights reserved.