Affinity of estrogens for human progesterone receptor A and B monomers and risk of breast cancer: a comparative molecular modeling study

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Hasan and Masoodi and Grace and Shafi and Alshatwi (2011) Affinity of estrogens for human progesterone receptor A and B monomers and risk of breast cancer: a comparative molecular modeling study. Advances and Applications in Bioinformatics and Chemistry. p. 29. ISSN 1178-6949

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Abstract

This in silico study investigates interactions between human progesterone receptors (hPR A, B, AB) and steroid derivatives, including progesterone and estrogens, via molecular docking using AutoDock 4.2. hPR A showed higher ligand affinity than hPR B or the AB dimer. Persistent exposure to estrogens, particularly hPR A, may increase breast cancer risk. © 2011 Hasan et al, Dove Medical Press Ltd. © 2012 Elsevier B.V., All rights reserved.

Item Type: Article
Subjects: Biochemistry, Genetics and Molecular Biology > Cancer Research
Divisions: Engineering and Technology > Aarupadai Veedu Institute of Technology, Chennai > Bio-technology
Depositing User: Unnamed user with email techsupport@mosys.org
Last Modified: 10 Dec 2025 06:43
URI: https://vmuir.mosys.org/id/eprint/4119

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