The Benzopyran derivatives are present many of biological sources and having wide variety of pharmacological activities .They act as antitumor agents and have photo chromic effects.Pharmacological study of these derivatives showed antispasmodic activity and possess a higher level of coronary dilatory action.Benzopyran derivatives also have a beneficial effects in preventing some type of anaphylaxis in animals and anti allergic or anti asthmatic action in human. Chromene also possess antimicrobial activities against gram positive and gram negative microorganisms.The synthesized chloro substituted derivatives shows consequence to moderate anti-inflammatory activity. © 2020 Elsevier B.V., All rights reserved.