The petroleum ether and methanol crude extracts of Rhizopora apiculata (L) (Rhizoporaceae) were screened for cytotoxicity by MTT bioassay and antioxidant activity using three different methods. The active constituents of the plant Rhizopora apiculata (L) were extracted using petroleum ether and methanol. Both extracts were tested for cytotoxicity by MTT assay at a concentration range of 18.75, 37.5, 100, 150 and 300µg/ml. The percentage cell viability shown in Pet ether extract for human cervical adenocarcinoma cell lines (HeLa), human osteosarcoma cell lines (MG 63) and Breast adenocarcinoma (MC 67) were in the range of 102-91%, 100-84% and 101-78% respectively shows that pet ether extract does not have considerable cytotoxic activity. On the other hand, Petroleum ether and methanol crude extracts of Rhizopora apiculata (L) showed mild antioxidant activity with compared to ascorbic acid. © 2020 Elsevier B.V., All rights reserved.