Studies on 2-((2, 4-dihydroxybenzylidene) amino)-3-phenylpropanoic acid include antimicrobial, antidiabetic, antioxidant, anticancer, hemolysis, and theoretical QSAR

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Ayyadurai, Gandhimathi Kaliyamoorthi and Jayaprakash, R. and Shajahan, Abdul Salam and Rathika, S. (2025) Studies on 2-((2, 4-dihydroxybenzylidene) amino)-3-phenylpropanoic acid include antimicrobial, antidiabetic, antioxidant, anticancer, hemolysis, and theoretical QSAR. Journal of Biomolecular Structure and Dynamics, 43 (6). 2864 - 2876. ISSN 07391102; 15380254

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Abstract

This study synthesized a chiral L-phenylalanine Schiff base with 2,4-dihydroxy benzaldehyde and evaluated its biological activities, including antimicrobial, antidiabetic, antioxidant, cytotoxicity (MTT) against HeLa cells, and hemolysis. The compound showed inhibition against K. pneumoniae, S. aureus, and Candida albicans (MIC: 35–45 ppm), and IC50 values between 138–265 μg/mL in other assays. Molecular docking, drug-likeness, and HOMO-LUMO analysis supported the experimental results, showing good binding affinity and agreement with commercial drugs.

Item Type: Article
Additional Information: Cited by: 3
Uncontrolled Keywords: 2 ((2, 4 dihydroxybenzylidene) amino) 3 phenylpropanoic acid; amylase; phenylalanine; propionic acid derivative; Schiff base; unclassified drug; antidiabetic agent; antiinfective agent; antineoplastic agent; antioxidant; antidiabetic activity; antimicrobial activity; antineoplastic activity; antioxidant activity; Article; binding affinity; breast cancer; Candida albicans; carbon nuclear magnetic resonance; cell viability; chemical structure; controlled study; density functional theory; disk diffusion; DPPH radical scavenging assay; enzyme activity; Fourier transform infrared spectroscopy; HeLa cell line; hemoglobin determination; hemolysis; human; human cell; IC50; Klebsiella pneumoniae; male; minimum inhibitory concentration; molecular docking; MTT assay; nuclear magnetic resonance spectroscopy; photoluminescence; proton nuclear magnetic resonance; quantitative structure activity relation; Staphylococcus aureus; thin layer chromatography; chemistry; drug effect; microbial sensitivity test; Anti-Infective Agents; Antineoplastic Agents; Antioxidants; HeLa Cells; Hemolysis; Humans; Hypoglycemic Agents; Microbial Sensitivity Tests; Molecular Docking Simulation; Quantitative Structure-Activity Relationship; Schiff Bases
Subjects: Pharmacology, Toxicology and Pharmaceutics > Drug Discovery
Divisions: Engineering and Technology > Vinayaka Mission's Kirupananda Variyar Engineering College, Salem > Bio-technology
Depositing User: Unnamed user with email techsupport@mosys.org
Date Deposited: 26 Nov 2025 07:15
Last Modified: 26 Nov 2025 07:15
URI: https://vmuir.mosys.org/id/eprint/353

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