Identification and Characterization of Candidate Platelet Proteins as Potential Biomarkers for Alcoholism Patients

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Kademani, Sangeetha P. and Subramanian, Vithiavathi Siva and Nelaturi, Prabhudas (2025) Identification and Characterization of Candidate Platelet Proteins as Potential Biomarkers for Alcoholism Patients. Alcoholism Treatment Quarterly, 43 (1). 40 - 53. ISSN 07347324; 15444538

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Abstract

This study investigates platelet proteome changes and apoptosis in 23 chronic alcoholism patients with alcohol-related liver disease (ARLD) using mass spectrometry. 441 proteins were identified, with 73 selected as candidate biomarkers related to coagulation, inflammation, and cellular interactions. Key proteins include von Willebrand factor, vitronectin, and serpin family members. Findings suggest that platelet proteome alterations could serve as noninvasive biomarkers for diagnosis, monitoring, and treatment of ARLD.

Item Type: Article
Additional Information: Cited by: 0
Uncontrolled Keywords: alanine aminotransferase; albumin; alkaline phosphatase; aspartate aminotransferase; bilirubin; biological marker; gamma glutamyltransferase; lipocortin 5; protein; proteome; serine proteinase inhibitor; vitronectin; von Willebrand factor; adult; alcohol liver cirrhosis; Alcohol Use Disorders Identification Test; alcoholism; apoptosis; Article; blood clotting; cell interaction; clinical article; clinical significance; controlled study; diagnostic test accuracy study; diagnostic value; disease exacerbation; female; Fibrosis-4 Index; gene ontology; hemostasis; hepatic encephalopathy; human; inflammation; international normalized ratio; leukocyte count; liquid chromatography-mass spectrometry; male; middle aged; Model For End Stage Liver Disease Score; non invasive measurement; platelet count; thrombocyte
Subjects: Biochemistry, Genetics and Molecular Biology > Clinical Biochemistry
Divisions: Medicine > Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem > Pharmacology
Depositing User: Unnamed user with email techsupport@mosys.org
Date Deposited: 26 Nov 2025 07:18
Last Modified: 26 Nov 2025 07:18
URI: https://vmuir.mosys.org/id/eprint/349

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