Aim: The purpose of this in vitro research is to chemically characterize polymethyl methacrylate (PMMA) processed with 10% and 20% (v/v) tricyclodecane dimethanol diacrylate (TCDDMDA) comonomer. It also aimed to assess the degree of conversion (DC) and glass transition temperature (Tg) of the formed copolymers. Materials and methods: The experimental groups were processed with the TCDDMDA comonomer (10% and 20% v/v), whereas the control group was processed only with the methyl methacrylate monomer. The copolymerization was studied by nuclear magnetic resonance (NMR) spectroscopy. The surface characteristics and composition (wt%) were studied by field-emission scanning electron microscopy (FESEM) and energy dispersive X-ray (EDX) spectroscopy (cuboidal specimen; 5 mm x 5 mm x 3 mm), respectively. The DC and Tg of the formed copolymers (powdered form) were analyzed by Fourier transform infrared spectroscopy and differential scanning calorimetry, respectively. One-way analysis of variance with post hoc Bonferroni test was used to compare the mean values of DC% and Tg among the groups. Results: The newly formed copolymer [P(MMA-co-TCDDMDA)] was chemically characterized by NMR and FESEM-EDX. The DC and Tg of the experimental groups were higher than the control. Tricyclodecane dimethanol diacrylate at 20% (v/v) concentration showed the highest DC and Tg. Conclusion: The addition of TCDDMDA comonomer improved the DC and Tg of the formed copolymer. Clinical significance: The P(MMA-co-TCDDMDA) copolymer is expected to improve the mechanical properties and biocompatibility of the denture base acrylic resin. This would result in improved denture quality and durability, thereby, imparting a better quality of life to the geriatric population. © 2020 Elsevier B.V., All rights reserved.