Polyglandular polyendocrine syndromes (PSs) are an assorted collection of infrequent ailments considered by autoimmune motion contrary to more than one endocrine organ, though non-endocrine organs can be affected. The defi-ciency of parathyroid is quite rare without surgery. This article summarises clinical, epidemiological, and serological, data of patients with PSs. Multi-faceted diagnostic difficulties and treatment choices required that the patient be admitted to the hospital for a rather long period, namely for six weeks. Three diabetic patients with various thyroid disorders such as lymphocytic thyroiditis involving parathyroid glands manifesting with severe hypothy-roid and hypo-parathyroid status were studied with an occurrence of dengue viral aetiology as a precipitating factor. Further, the patients were investi-gated for the determination of antibodies against thyroglobulin and microso-mal antigens by chemiluminescent microparticle immunoassay. They were also tested for Parathyroid Hormone and 25-hydroxy vitamin D. After three months, all the three hormonal status were brought to normal with substitu-tion and maintenance therapy, and patients were reviewed after six months were found to maintain with the dose. To conclude, thyroiditis may progress during the progression of dengue fever and should be counted as a manifestation of expanded dengue syndrome. © 2020 Elsevier B.V., All rights reserved.