Impact of Rhenium(I)-Diselenoether Compound on Cell Adhesion, Migration, Invasion Capacities, and MMP-2 Release in MDA-MB-231 Breast Cancer Cells

Dimensions

Collery, Philippe and Desmaẽle, Didier and Harikrishnan, Adhikesavan and Veena, Vijay Kumar (2025) Impact of Rhenium(I)-Diselenoether Compound on Cell Adhesion, Migration, Invasion Capacities, and MMP-2 Release in MDA-MB-231 Breast Cancer Cells. Anticancer Research, 45 (1). 73 - 79. ISSN 02507005; 17917530

Full text not available from this repository.

Abstract

This study investigates the anti-invasive effects of a rhenium(I)-diselenoether (Re-diSe) compound on MDA-MB231 triple-negative breast cancer cells. Using adhesion, migration, and transwell invasion assays, Re-diSe was effective at low concentrations (5–10 μM), with 120 h exposure showing the greatest reduction in invasion. Re-diSe also influenced MMP-2 levels in the cell medium, indicating its potential as a therapeutic agent to inhibit cancer cell invasion and metastasis.

Item Type: Article
Additional Information: Cited by: 0; All Open Access; Hybrid Gold Open Access
Uncontrolled Keywords: crystal violet; diselenoether; gelatinase A; matrigel; metal complex; rhenium; selenium derivative; unclassified drug; antineoplastic agent; MMP2 protein, human; Article; cell adhesion; cell invasion; cell migration; concentration response; controlled study; drug exposure; extracellular matrix; fluorometry; human; human cell; MDA-MB-231 cell line; protein secretion; transwell assay; triple negative breast cancer; wound healing assay; breast tumor; cell motion; chemistry; drug effect; drug therapy; female; metabolism; pathology; tumor cell line; tumor invasion; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Rhenium; Triple Negative Breast Neoplasms
Subjects: Biochemistry, Genetics and Molecular Biology > Cancer Research
Divisions: Arts and Science > Vinayaka Mission's Kirupananda Variyar Arts & Science College, Salem > Chemistry
Depositing User: Unnamed user with email techsupport@mosys.org
Date Deposited: 26 Nov 2025 07:22
Last Modified: 26 Nov 2025 07:22
URI: https://vmuir.mosys.org/id/eprint/343

Actions (login required)

View Item
View Item