Medicinal plants are a vital source of medicines worldwide. Over 3000 plants are registered in India for medicinal use, and more than 6000 are traditionally used for various remedies. Cassia species, perennial trees growing in rough land areas in India and Sri Lanka, contain essential phytochemicals such as phenolic compounds, flavonoids, and anthraquinone glycosides. Traditionally, Cassia species are used for laxative purposes, skin disorders, liver diseases, and worm infections. This review focuses on the ethnobotanical, phytochemical, and pharmacological activities of Cassia marginata Roxb. © 2020 Elsevier B.V., All rights reserved.