In today's world of manufacturing industries, especially automotive sectors that expect high productivity, quality, and accuracy, dependence on industrial robots is increasing more than on human labor. A robot cell is a part of the manufacturing environment, composed of one or more robots with controllers, and is becoming popular in automobile industries for operations like welding, assembling, and painting. Issues with the design of robotic cell layouts play a major role in achieving better production rates and safety. This paper discusses critical issues with robotic cell layouts and optimization of work cell layout after analysis for elimination of errors. © 2021 Elsevier B.V., All rights reserved.