Background: Acne vulgaris is a widespread dermatological condition, particularly prevalent among adolescents and young adults. Despite their commonality, the variability in treatment practices has made it essential to reassess current prescribing practices and treatment strategies. Aim: Relating the clinico-epidemiological features of acne vulgaris and evaluating the treatment strategies and drug prescribing practices in a tertiary care hospital. Materials and methods: A prospective observational study was conducted with 100 patients in the dermatology department of a tertiary care hospital from January to June 2024. Sociodemographic data were collected through patient interviews, and detailed dermatological assessments were performed by dermatologists to categorize acne severity and identify common triggers. Results: Statistical analysis of the results was expressed in percentages. The majority of patients were aged between 18 and 27 years, with a higher prevalence among females. Most patients were students, residing in urban areas, with moderate to severe acne. The most common treatment regimen involved a combination of topical retinoids, antibiotics, and isotretinoin prescribed for severe cases. Conclusion: This study highlights the importance of improving acne treatment strategies, focusing on personalized approaches to improve patient outcomes. There is a critical need for continuous education among healthcare providers regarding emerging treatment options and best clinical practices in acne management. © 2025 Elsevier B.V., All rights reserved.