This study applies a reverse vaccinology and immunoinformatics approach to design a potential vaccine candidate against Influenza A virus (H1N1). The vaccine construct includes epitope segments recognized by B- and T-cells linked with adjuvants. Computational analyses indicate high antigenicity, immunogenicity, and safe interaction with immune receptors. Molecular docking and dynamics simulations confirm stable binding, while immune response modeling suggests effective immune activation. These findings highlight the construct's potential for further preclinical development as an IAV vaccine.