Introduction: The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (TKs), control many develop-mental, metabolic and physiological procedures. Objectives: To evaluate different aspects of tumour dynamics through the immunohistochemical evaluation of EGFR expression in OSCC and its correlation with proliferation. Methods: A total number of 35 cases are included in the study, comprising of 5 histologically proven normal cases, 10 histologi-cally proven cases of epithelial dysplasia, 10 histologically proven cases of well-differentiated squamous cell carcinoma and 10 histologically proven cases of moderately differentiated squamous cell carcinoma. Serial sections of 3 µm were obtained from the archival blocks using a standard microtome. They were evaluated by histologic examination. Results: There is a significant association was found between the level of intensity of staining and group. Since the p-value is less than 0.05 there is a significant association was found between the grading of overall staining and group. Conclusion: Based on our observation, it may be concluded that EGFR can be considered as an early marker of cell proliferation on cell differentiation as well as an early marker of epithelial dysplasia and onset of cancer. © 2021 Elsevier B.V., All rights reserved.