Drug use is a complex process uncertainties in diagnosis, treatment and medication adherence contribute to wide variations in the way drugs are used for any given conditions. In any country, a large number of sociocultural factors also contribute to the way drugs are used. In India, this include national drug policy, illiteracy, poverty, use of multiple health care systems, drug advertising and promotion, same of prescription drugs without prescription, competition in the medical and pharmaceutical marketplace and limited availability of and unbiased drug information. The complexity of drug use means that optimal benefits of drug therapy in patient care may not be achieved because of under use, over use or misuse of drugs. One method to evaluate and improved drug use is conducting drug use evaluation studies. Method: This study was prospective observational study in multi-specialty hospitals in Narasaraopet at Guntur district Andhra Pradesh Results: The study was conducted from August 2018 to Dec 2019 in various multi-specialty hospitals in Narasaraopet at Guntur district Andhra Pradesh. Total three departments we collected data Pediatrics, orthopedic, gynecology A total of 435 patients were participated in the current study out of 153 (35%) were males and 282 (65%) were females. In this study most common group antibiotics is cephalosporin’s 152 (34.9%) out of 435 of which mostly cefitriaxone are most commonly prescribed 70 (46%) Conclusion: Study provides the information about the prospective study of antibiotics utilization in multi-specialty hospital. It has helped to identify irrational prescribing patterns of drugs in various departments like pediatrics, gynaecology orthopedic. © 2021 Elsevier B.V., All rights reserved.