A half of a sphere of existence is intimidated by substantial exploitation and uncontrolled release of pharmaceutical chemical pollutants which damage the environment and require instantaneous remediation. This work examines the electrochemical perseverance of the antimicrobial drug sulfathiazole (STZ). The disadvantageous consequence of the drug revealed the consequence of its constructive detection and the growth of acceptable materials for the sensing approach. The deep eutectic solvent-based contriving of yttrium sulfide nanoparticles/graphitic carbon nitride heterostructure (Y2S3@CNS) allows an approachable green synthesis of the composite with exceptional properties. The hierarchical structure of Y2S3@CNS composite offers synergistic quantum imprisonment effects and incarcerated charge conveyors recommend active imprisoning sites. The modified electrocatalytic activity of the suggested drug sensor supports its use with display higher sensitivity, wide linear-range responses (0.02-1534.5 μM), a lower limit of detection (6.2 nM), considerable stability, and high selectivity. Investigation of real samples with the establish electrocatalyst stimulates its experiential solicitation in the real world. © 2021 Elsevier B.V., All rights reserved.